| Slabbert Custom Furniture | Cape Town | Manufacturer, Retail, Marketing and Sales | |
| Sleet Consultancy | Stellenbosch | Copywriting, Proofreading, Social Media, PR | |
| Slow Life | Cape Town | South African music promotion | |
| Slum Dwellers International | Cape Town | Global network of the urban poor | |
| Smart Art Digital and Interior Design CC | Cape Town | Printing, Design, Mask Production, Branding, | |
| Smart Digital Media | Paarl | Web Design, Hosting, Print, Graphic design | |
| Smart Staff | Cape Town | Staff training & on-boarding via mobile | |
| Smart-It Accounting Software | Bellville | Accounting software | |
| SmartBrain Child Development Institute | Cape Town | Helping children with learning disabilities | |
| Smith and van Lierop Dentistry | Cape Town | Dentist | |
| Smokie - Licious Woof & Pookie Doggie Day Care | | Dog Boarding/Traiining/Grooming/Walking | |
| SMSDepot | Cape Town | Bulk SMS and Direct marketing | |
| Soak Productions | | Animation, Illustration, Design, Direction | |
| Soapbox Communications | Cape Town | Media relations and communications consultancy | |
| Social Distancing Stickers | Cape Town | Marketing, Printing, eCommerce, Social Distancing | |
| Social Media Shop | Cape Town | Social Media Marketing and Advertising | |
| Social Media Training Somerset West | Lochtec | Cape Town | Lochtec Innovations in Somerset West, Cape Town, | |
| Social Natives | Cape Town | Social Media Management | |
| Socio-Dex | Cape Town | Research & Advisory firm | |
| Solar Advice | Cape Town | Online Distribution | |
| Solar Solved Africa | Cape Town | Renewable energy product supplier | |
| Solid Systems | Cape Town | Microsoft Specialists | |
| Solo Graphica | Cape Town | Graphic Design | |
| Solutions Connect Training and Consulting Africa | Bettys Bay | Innovation and Service Consulting and Training | |
| Solutions Medical Wheelchairs | Goodwood | Medical equipment | |
| solved | Somerset West | wine industry recruitment | |
| Somerset West Web Design and Development | Cape Town | Web Development | |
| Somila Facilities Services | Cape Town | Professional Cleaning Services | |
| Sonar Studios | Cape Town | Music Composition, ADR, Final Mix, Sound Design | |
| Sonnenberg & Associates Property & Legal Advice | Cape Town | Property and legal advice | |
| Soon Master Technology | | Haizhu District Zhongzhou Trading Center | |
| Sorted Design + Advertising | Cape Town | Graphic Design, Advertising, Web Design, Branding | |
| Soulogical Daily Planner & Life Guide | Atlantis | Journal/diary + a daily spiritual & Health guide | |
| Sound & Motion Studios | Cape Town | Recording and Production, Music and Film | |
| Sound As Good As You Look | Cape Town | Communications training | |
| Sound Stylists (Pty) Ltd | Cape Town | Full Technical Turnkey solutions | |
| Sound Surgeon Studios | Cape Town | Score, Recording, Sound Design, Foley, Mixing | |
| SoundProof Discos | Cape Town | Mobile Dj's and Sound and Light Sales | |
| Source Content Marketing Agency | | Content Marketing | |
| South Africa Travel | Cape Town | Travel Services, Travel Agency, Tour Operators | |
| South African Hotels | Cape Town | Travel Agency | |
| Southern Staying South Africa | Struisbaai | Vacation Accommodation Service Providers | |
| Southern Summit | Cape Town | Exporting vegetables and fruit from South Africa | |
| Southgate Courier Services | Cape Town | Import and Export Courier Services | |
| Sovrn Coffee | Cape Town | Specialist Coffee Roastery, Beans and Equipment | |
| SP Supplies | Cape Town | Print, Design, Branding, Office Supplies | |
| Spartan Technologies | | Computer Online Store | |
| Spearhead | | Video, design and content production | |
| Special Carpet Cleaning | | Carpet cleaning | |
| Specialist Physician | Dr Tony Tom | Cape Town | Medical Practice | |
| Specialist Physician | Dr Zaraina Solomons | Cape Town | Medical Practice | |
| Specials on Sales | Somerset West | Shopping | |
| Speck Pumps South Africa | Cape Town | pool pumps | |
| Specter Marketing | Cape Town | Website Development | |
| Spectrum AV | Cape Town | Hire of audio visual equipment & services | |
| Spektrum video productions | Cape Town | Video production house | |
| Sphere ICT | Cape Town | Cyber Security Specialists. ICT | |
| Spika | South Africa | Design & illustration | |
| Spit Braai Delivery | Cape Town | Spit Braai Catering | |
| Splash PR & Media Consultants | Cape Town | Media Relations; Social Influencer Marketing | |
| Sportsman Events | Cape Town | Team Building, Family Fun Days, Sports Days, Confe | |
| Spotlight Agency | Cape Town | Promotional Staffing | |
| SQ Garage Doors and Gate Systems | Cape Town | Install and repair garage doors + motors +gates | |
| ST Communications | Cape Town | Brainwave Projects 2298cc | |
| St John's Christian Brothers' College | Cape Town | School | |
| Staff Training | Cape Town | Training | |
| Stanford Payne Coaching | Stellenbosch | Executive Entrepreneur Business Career Coaching | |
| Staplenet systems | Cape Town | No.1 provider for total DSTV, home entertainment | |
| Star Trackers | Cape Town | Entertainment | |
| STARC | Cape Town | Residential and Commercial building design | |
| Start-Up Mentors | Cape Town | Startup: Business Coaching, Mentoring and Training | |
| StateoftheART Gallery | Cape Town | Contemporary Art Gallery | |
| Steam And Valves Specialists | Cape Town | Steam And Valve Specialists | |
| Steel & Pipes for Africa - Cape Town | Cape Town | Supplying steel products | |
| Steele Storage Systems | Cape Town | Shelving, Racking, Bulk Filing Systems | |
| Steelworks Fabrication Services | Blackheath | Fabrication of steel products | |
| Stella-Rose Skin | Cape Town | Children's Skin Care Range | |
| Stellar Radio Networks | Cape Town | Retail Radio Broadcast and Instore Audio Services | |
| Stellenbosch University LaunchLab | Stellenbosch | Startup Programmes, Events | |
| Stephanie Photography | Cape Town | Cape Town Photographer | |
| Stephanie Rouillard | Cape Town | Dietitian | |
| Sterling Hospitality | Cape Town | Hotel Resort Management/Development | |
| Stettyn Cellar | Villiersdorp | Wine | |
| Stiltz Home Lifts | Cape Town | Home lifts, home elevators, residential lifts | |
| Stobel Cape | Cape Town | Warehousing and Transport | |
| Stock Counters | Cape Town | Stocktaking | |
| Stoked Surf | Cape Town | Surf Lessons, Surf Guiding, Surf Trips and SUP | |
| Stoneworks Signage & Print cc | Cape Town | 3D Printing, Graphic Design, Digital Printing | |
| Storage Chief | Brackenfell Cape Town | Storage Chief | |
| StorageBuddy | | Self storage company | |
| Store Fast | Cape Town | Self storage | |
| Storehub.io | Cape Town, | Storehub.io | |
| Stormtech | Cape Town | Business software development and web applications | |
| Story2Voice | Cape Town | Voice Work | |
